Description
Retinoic acid (RA), a retinoid, exerts a broad range of biological effects. It plays a role in regulating cellular differentiation and proliferation in both normal and transformed cells, potentially influencing oncogenes. All-trans retinoic acid (ATRA) is regarded as the most pertinent and functionally active metabolite of Vitamin-A. RA may serve as a type of signal molecule through a nuclear receptor to regulate regional differentiation in the central nervous system. Moreover, at a concentration of 1 nM (with maximal differentiation at 1 µM), RA induces morphological and functional terminal differentiation in a cell line of human promyelocyte leukemia, indicating its potential involvement in the differentiation of specific hematopoietic cells. Additionally, RA can indirectly impact neuronal differentiation by modifying the expression of neuronal cell surface receptors to peptide growth factors.
Application
Retinoic acid (RA) has been used for the differentiation of embryonic stem cells into motor neurons
It has been used for the differentiation of Xenopus ectoderm into pancreas
It has also been used to study epigenetic regulation by RARα (retinoic acid receptor α).
It has been used to study RA signaling of prospermatogonia transition into spermatogonia
About This Item
Formula : C20H28O2
CAS Number: 302-79-4
Molecular Weight: 300.44
form: powder
color: yellow
solubility: chloroform: 50 mg/mL
storage temp: −20°C
