Streptozocin (STZ)
≥75% α-anomer basis,≥98% (HPLC), powder, DNA alkylating agent
کد معادل: S0130 Sigma
Dscription
Streptozocin (STZ) is an antineoplastic antibiotic. This N-nitroso-containing compound acts as a nitric oxide donor in pancreatic islets. It is a methylnitrosourea attached to a single molecule of glucosamine and has a high affinity for the cell surface glucose transporter glucose transporter type 2 (GLUT2), which is highly expressed on beta cells of the islets of Langerhans. Streptozotocin cannot pass through the blood-brain barrier, but its metabolites are usually seen in the cerebrospinal fluid.
Application
Streptozocin or streptozotocin is used to induce type 1 diabetes for medical research.
About This Item
Formula : C8H15N3O7
CAS Number: 18883-66-4
Molecular Weight: 265.22
form: powder
color: white to light yellow
storage temp: -20°C
antibiotic activity spectrum: neoplastics
